Table 2.

Analgesic activity of Compounds 1−6 in comparison with initial terpenoids 7−12 on Phase I of the formalin test in mice (2% w/w ointment).

Compound	Licking Time (s)	Compound	Licking Time (s)
Control	103 ± 8.5	6	30 ± 5.6
Benzocaine	36 ± 2.4	7	24 ± 5.6
1	19 ± 3.7	8	50 ± 5.2
2	47 ± 1.3	9	38 ± 3.8
3	29 ± 6.9	10	54 ± 6.8
4	35 ± 1.9	11	26 ± 4.7
5	19 ± 1.5	12	40 ± 3.3

All values are expressed as mean ± SEM; n = 6; for all groups p < 0.01 compared with control. One-way analysis of variance (ANOVA) followed by Tukey’s post hoc comparison.