Table 4.
Analgesic activity of Compounds 1−6 in comparison with initial terpenoids 7−12 on capsaicin-induced acute pain in mice (2% w/w ointment).
| Compound | Licking Time (s) | Compound | Licking Time (s) |
|---|---|---|---|
| Control | 46 ± 1.8 | 6 | 18 ± 0.9 * |
| Benzocaine | 29 ± 6.6 * | 7 | 11 ± 2.7 ** |
| 1 | 11 ± 1.5 ** | 8 | 35 ± 4.1 |
| 2 | 16 ± 3.2 * | 9 | 23 ± 6.4 * |
| 3 | 14 ± 0.8 * | 10 | 23 ± 2.7 * |
| 4 | 20 ± 3.6 * | 11 | 12 ± 5.0 * |
| 5 | 15 ± 1.3 * | 12 | 20 ± 3.4 * |
All values are expressed as mean ± SEM; n = 6; * p < 0.05 compared with control group, ** p < 0.01 compared with benzocaine. One-way analysis of variance (ANOVA) followed by Tukey’s post hoc comparison.