Table 1.
Inhibitory effects of CDXs on COX-1 and COX-2.
| CDX | COX-1 | COX-2 |
|---|---|---|
| (S)-(−)-CDX1 | 87.6 ± 2.1 | 80.1 ± 12.8 |
| (R)-(+)-CDX1 | 79.6 ± 5.0 | 84.7 ± 5.7 |
| (S)-(−)-CDX2 | 82.9 ± 5.2 | 85.7 ± 4.5 |
| (R)-(+)-CDX2 | 66.8 ± 1.6 | 73.2 ± 0.4 |
| (S)-(+)-CDX3 | 91.7 ± 10.7 | 93.4 ± 11.4 |
| (R)-(−)-CDX3 | 75.2 ± 9.0 | 75.1 ± 7.2 |
| Indomethacin | 83.2 ± 6.4 | 80.7 ± 9.5 |
Values correspond to percentage of enzyme inhibition (mean ± standard deviation). Each compound was analyzed in triplicate in two independent days. The concentration of CDXs was 20 µmol/L. Indomethacin 1 µmol/L was used as positive control.