Table 3.

HSA binding parameters obtained for the CDXs and predicted docking scores between HSA and CDXs.

Compound		Kd	Ymax	∆G Binding	Docking Score (kcal/mol)
Known ligands	Azaprozone				−5.9
	Diazepam				−7.1
	Fusidic acid				−5.8
	(S)-Ibuprofen				−7.3
	Iophenoxid acid				−4.4
	Naproxen				−7.9
	Warfarin				−8.5
(R)-(+)-CDX1		61.8 ± 6.5	109.6 ± 1.6	−2.4 ± 0.2	−7.3
(S)-(−)-CDX1		23.6 ± 0.8	105.3 ± 0.4	−1.9 ± 0.1	−7.0
(R)-(+)-CDX2		29.2 ± 0.9	108.2 ± 0.2	−2.0 ± 0.1	−7.2
(S)-(−)-CDX2		24.7 ± 1.1	107.4 ± 5.4	−1.9 ± 0.1	−7.2
(R)-(−)-CDX3		26.4 ± 1.2	113.2 ± 1.4	−1.9 ± 0.1	−7.2
(S)-(+)-CDX3		31.4 ± 2.0	116.2 ± 0.6	−2.0 ± 0.2	−7.0

Values correspond to the mean ± standard deviation of triplicate runs; K_d corresponds to the dissociation constant of CDX-HSA in μM; Y_max corresponds to the maximum percentage of HSA fluorescence quenching; ∆G for binding expressed in kcal/mol.