Figure 4.

(A) Percentage of γ-H2AX-positive nuclei and (B) percentage of positive nuclei per glomerulus (N/G) in kidneys of mice two weeks after injection of ¹⁷⁷Lu-folate. Compared to the kidneys of untreated mice which showed rare positive cells, there is a dose-related, statistically significant increase in the number of γ-H2AX-positive nuclei in mice euthanized two weeks after injection (≥10 MBq ¹⁷⁷Lu-folate). The highest activity of ¹⁷⁷Lu-folate was associated with a statistically significant increase in the number of γ-H2AX-positive nuclei in glomerular cells at the two-week time point (B). *p < 0.05.