Table 3.
COPD exacerbations during the past year
| COPD exacerbation | Total (n=1,008) | ACOS defined by syndromic features and FEV1 variability ≥12% and ≥200 mL
|
ACOS defined by syndromic features and FEV1 variability ≥12% and ≥400 mL
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| ACOS (n=93) |
COPD alone (n=915) |
Ratio* | P-value | ACOS (n=42) |
COPD alone (n=966) |
Ratio* | P-value | ||
| Any | |||||||||
| No of patients (%) | 284 (28.2) | 25 (26.9) | 259 (28.3) | – | 0.810# | 12 (28.6) | 272 (28.2) | – | 1.000# |
| No of events (rate) | 502 (0.498) | 53 (0.570) | 449 (0.491) | 1.161 | 0.502‡ | 31 (0.738) | 471 (0.488) | 1.514 | 0.176‡ |
| Moderate or severe | |||||||||
| No of patients (%) | 265 (26.3) | 24 (25.8) | 241 (26.3) | – | 1.000# | 12 (28.6) | 253 (26.2) | – | 0.722# |
| No of events (rate) | 452 (0.448) | 48 (0.516) | 404 (0.442) | 1.169 | 0.497‡ | 29 (0.690) | 423 (0.438) | 1.577 | 0.147‡ |
Notes:
*
ACOS:COPD alone.
#
Fisher’s exact test.
‡
Negative binomial regression analysis.
Abbreviations: ACOS, asthma–COPD overlap syndrome; FEV1, forced expiratory volume in 1 second; No, number.