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. Author manuscript; available in PMC: 2017 Jun 29.
Published in final edited form as: Cell. 2015 Nov 5;163(4):988–998. doi: 10.1016/j.cell.2015.10.027

Figure 3. PLSDA and LASSO identify unique combinations of features that differentiate vaccine trial Ab profiles.

Figure 3

(A) The scores plot represents the RV144 (red) and VAX003 (blue) vaccine profile distribution for each vaccinee tested (dots) from the LASSO and PLSDA. Remarkably, as few as, 7 Ab features, listed on the loadings plot (B), separated the vaccine profiles with 100% calibration and 97% cross-validation accuracy. LV1 captured 61% of X variance and 72% of the Y variance. (C) LASSO and PLSDA of all 4 vaccine profiles identified 15 Ab features (D) able to discriminate between the distinct vaccine regimens (red, RV144; blue, VAX003; green, HVTN204; and yellow, IPCAVD001) with 84% cross validation accuracy. Together LV1 and LV2 captured 57% of the X variance and 45% of the Y variance, respectively. See also Tables S1 and S2.