Table 1.

Echocardiography

	No Iso Infusion		7-d Iso Infusion		p Value
	Con (28)	C1C2 (29)	Con (6)	C1C2 (6)	Interaction	Iso	Gene
Heart rate, beats/min	530 ± 10	521 ± 17	508 ± 7	499 ± 3	0.99	0.31	0.68
End-diastolic dimension, mm	3.9 ± 0.1	4.0 ± 0.1	4.0 ± 0.2	3.9 ± 0.1	0.56	0.91	0.88
End-systolic dimension, mm	2.5 ± 0.1	2.6 ± 0.1	2.7 ± 0.2	2.7 ± 0.1	0.68	0.25	0.90
% Fractional shortening	38 ± 2	36 ± 2	32 ± 2	31 ± 2	0.85	0.04	0.70

Values are mean ± SE; (group size), p values are from 2-way ANOVA.

7-day Iso = 7 days continuous isoproterenol infusion; C1C2 = transgenic mice with cardiac-directed C1C2 expression; Con = transgene-negative sibling mice used as controls.