Table 2.
LV Pressure Development and Decline
| No Iso Infusion |
7-d Iso Infusion |
p Value |
|||||
|---|---|---|---|---|---|---|---|
| Con (12) | C1C2 (13) | Con (10) | C1C2 (8) | Interaction | Iso | Gene | |
| LV peak +dP/dt, mm Hg/s | 5,070 ± 553 | 4,319 ± 253 | 3,911 ± 406 | 5,298 ± 174∗ | 0.012 | 0.83 | 0.44 |
| LV peak −dP/dt, mm Hg/s | -5,003 ± 527 | -4,362 ± 248 | -3,485 ± 321 | -5,524 ± 149† | <0.001 | 0.64 | 0.07 |
| LV pressure, mm Hg | 78 ± 4 | 72 ± 2 | 62 ± 3‡ | 80 ± 1§ | <0.001 | 0.05 | 0.19 |
| Heart Rate, beats/min | 458 ± 19 | 439 ± 19 | 447 ± 10 | 481 ± 17 | 0.16 | 0.40 | 0.68 |
Values are mean ± SE, (group size). There were no baseline between-group differences (Con vs. C1C2) in LV peak +dP/dt (p = 0.22), LV peak −dP/dt (p = 0.27), LVP (p = 0.18) or heart rate (p = 0.49).
LV = left ventricle; other abbreviations as in Table 1.
∗
p = 0.026 vs. C1C2 No Iso; †p = 0.006 vs. C1C2 No Iso; ‡p = 0.012 vs. Con No Iso; §p = 0.016 vs. C1C2 No Iso (post hoc within-group comparisons using Student’s t-tests with Bonferroni correction for multiple testing).