Table 5.
W11+ | W21 | W12 | W22 | |
---|---|---|---|---|
a: Death on Riva first | 202,868 (14.8%)# | 209,585.8 (15.1%) | 202,868 (13.8%) | 209,585.8 (14.0%) |
b: Death on Placebo first | 292,132 (21.4%) | 304,607.4 (22.0%) | 292,132 (19.8%) | 304,607.4 (20.4%) |
c: MI or Stroke on Riva first | 392,876 (28.7%) | 392,876 (28.3%) | 440,620.4 (29.9%) | 440,620.4 (29.5%) |
d: MI or Stroke on Placebo first | 480,285 (35.1%) | 480,285 (34.6%) | 536,990.6 (36.5%) | 536,990.6 (36.0%) |
Total: a + b + c + d | 1,368,161 | 1,387,354 | 1,472,611 | 1,491,804 |
Win ratio: (b + d)/(a + c) | 1.30 | 1.30 | 1.29 | 1.29 |
Reciprocal of Win ratio | 0.77 | 0.77 | 0.78 | 0.78 |
95% CI | (0.63, 0.94) | (0.63, 0.93) | (0.64, 0.95) | (0.63, 0.94) |
p-value* | 0.025 | 0.022 | 0.029 | 0.026 |
Wij is the weighted win loss statistics using weight (i) for the terminal event and weight (j) for the non-terminal event listed in Section 4.1;
the percentages in the parentheses are the contribution indexes as, for example, a/(a + b + c + d) × 100%;
p-values are from the tests based on the weighted win difference.