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. 2017 May 25;9(6):539. doi: 10.3390/nu9060539

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overview of one-carbon metabolism considering metabolites, enzymes, coenzymes, and genetic variants. Abbreviations: methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), reduced folate carrier (RFC), dihydrofolate reductase (DHFR), tetrahydrofolate (THF), cystathionine β-synthase (CBS), dihydrofolate (DHF), human folate receptor (hFR), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), thymidylate synthase (TS), deoxyuridine monophosphate (dUMP), deoxythymidine monophosphate (dTMP), Betaine--Homocysteine S-Methyltransferase (BHMT), dimethyglycine (DMG), glycinamide ribonucleotide (GAR), 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), glycinamide ribonucleotide transformylase (GART), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT).