Table 1.
Panel of genetic variants, minimum allele frequency, and Hardy-Weinberg equilibrium of the six polymorphisms involved in one-carbon metabolism.
| Polymorphisms | Location | Gene | Changes | p a | MAF | |
|---|---|---|---|---|---|---|
| DNA | Amino acids | |||||
| rs1801131 | 1p36.3 | MTHFR | A→C | Glu→Ala | 0.392 | 0.24 |
| rs1801133 | 1p36.3 | MTHFR | C→T | Ala→Val | 0.428 | 0.33 |
| rs1805087 | 1q43 | MTR | A→G | Asp→Gly | 0.333 | 0.19 |
| rs1801394 | 5p15.31 | MTRR | A→G | - | 0.154 | 0.42 |
| rs1051266 | 21q22.3 | RFC1 | G→A | His→Arg | 0.141 | 0.46 |
| 19-bp deletion | 5q11.2–q13.2 | DHFR | - | - | 0.807 | 0.47 |
a p-value for Hardy-Weinberg equilibrium. MAF, minor allele frequency; RFC-1, reduced folate carrier 1; DHFR, dihydrofolate reductase; MTHFR, 5,10-methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase.