Figure 2.

Melatonin regulates protein levels of cleaved PARP and p- p-eIF2α in the insulin stimulated SH-SY5Y neuronal cells. Protein levels of (A) cleaved PARP and (B) activation of eIF2α, (p-eIF2α) were measured by western blot analysis. Data are expressed as mean ± standard error and each experiment included three repeats per conditions. * p < 0.05 compared with non-stimulated control; ^φ p < 0.05 compared with insulin stimulated cells. Mel: melatonin pretreatment for 24 h before insulin stimulation.