Table II.
Baseline characteristics of interventional studies in short-term parenteral nutrition.
| Study | Population, n | Venous access | Intervention | Comparator | Outcome | Follow-up |
|---|---|---|---|---|---|---|
| Fabri, 198215 | 24 (adults) | Subclavian CVC | UFH 3,000 IU/L PN solution | No UFH | (a)symptomatic CRT | Not available |
| Brismar, 198214 | 49 (adults) | External jugular CVC | UFH 5,000 IU/6 hours | No UFH | (a)symptomatic CRT | <8 weeks |
| Ruggiero, 198319 | 34 (adults) | Subclavian CVC | UFH 1,000 IU/L PN solution | No UFH | (a)symptomatic CRT | <8 weeks |
| Fabri, 198416 | 40 (adults) | Subclavian CVC | UFH 3,000 IU/L PN solution | No UFH | (a)symptomatic CRT | <8 weeks |
| Macoviak, 198418 | 37 (adults) | Subclavian CVC | UFH 1 IU/mL PN solution | No UFH | (a)symptomatic CRT | <8 weeks |
| Kamala, 200217 | 68 (neonates) | PICC | UFH 1 IU/mL PN solution | No UFH | (a)symptomatic CRT; IVH | <6 weeks |
| Uslu, 201020 | 239 (neonates) | PICC | UFH 0.5 IU/kg/h PN solution | No UFH | (a)symptomatic CRT; IVH | <4 weeks |
All the studies evaluated UFH for primary prevention of asymptomatic CRT. PICC: peripherally inserted central venous catheter; PN: parenteral nutrition; RCT: randomised controlled trial; aPTT: activated partial thromboplastin time; IVH: intraventricular haemorrhage; CVC: central venous catheter; CRT: central venous catheter thrombosis; UFH: unfractionated heparin sodium; DIC: disseminated intravascular coagulation; AC: anticoagulant; ICU: intensive care unit.