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. 2017 Jun 19;127(7):2868–2880. doi: 10.1172/JCI92008

Figure 3. Bilateral nanoinjections of NPY or BIBO3304 into the PVN and DMH of WT mice decrease and increase SSNA, HR, and MAP, respectively.

Figure 3

(A and E). Representative experiments showing that injections (at thin arrow) of NPY into the PVN or DMH decrease raw SSNA, HR, and MAP. (B and F) Representative experiments showing that injections (at thin arrow) of BIBO3304 into the PVN or DMH increase raw SSNA, HR and MAP. (C) Grouped data showing that PVN NPY or BIBO3304 decreases or increases SSNA, HR, and MAP, respectively; PVN injections of aCSF had no effects. Baseline values were 88 ± 3 mmHg and 443 ± 15 bpm (n = 19). (G) Grouped data showing that DMH injections of NPY or BIBO3304 decrease or increase SSNA, HR, and MAP, respectively; DMH injections of aCSF had no effects. Baseline values were 86 ± 2 mmHg and 450 ± 12 bpm (n = 20). (D and H) Histological maps (based on ref. 80), and representative sections illustrating PVN and DMH injection sites. *P < 0.05, compared with time 0.