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. 2017 Jun 19;127(7):2662–2677. doi: 10.1172/JCI92508

Figure 5. RIPK1 regulates DEN-induced apoptotic death of hepatocytes.

Figure 5

(A) Graph depicting serum ALT levels of 6-week-old Ripk1fl/fl and RIPK1LPC-KO mice injected with an acute dose of DEN for the indicated time periods. ***P < 0.005, 1-way ANOVA. (B and D) Representative images of livers of noninjected or DEN-injected (acute dose) 6-week-old Ripk1fl/fl and RIPK1LPC-KO mice stained for CC3 (B), Ki-67 (C), and CC8 (D). Scale bars: 100 μm. Quantification of CC3+, Ki-67+, and CC8+ cells per field, mean of 5 fields per animal. ***P < 0.005, 1-way ANOVA.