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Structural comparison of the elbow loops of Cm eIF4G, metazoan eIF4Gs, and 4E-BP. A to D, Close-up views of the canonical helices and elbow loops of Cm eIF4G (A), Hs eIF4G (B), Dm eIF4G (C), and Dm Thor (as a m4E-BP model; D) bound to the dorsal surface of eIF4E (PDB IDs: 5T46, 5T47, 4UE8; Peter et al., 2015a; Grüner et al., 2016). Selected residues mediating phosphorylation and their analogs are shown as sticks.
