Table 2. Probability of escalation to the next higher dose for each underlying true DLT rate.
True underlying DLT | 5% | 10% | 20% | 30% | 40% | 50% | 60% | 70% | 80% | 90% |
Probabilty of escalating dose | 0.97 | 0.91 | 0.71 | 0.49 | 0.31 | 0.17 | .08 | 0.03 | 0.01 | 0.001 |
Probability of Failing to Observe toxicity if sample = 3 | 0.86 | 0.73 | 0.51 | 0.34 | 0.22 | 0.13 | 0.064 | 0.027 | 0.008 | 0.001 |
Probability of Failing to Observe toxicity if sample = 6 | 0.74 | 0.53 0.26 |
0.12 | 0.047 | 0.016 | 0.0041 | <0.001 | <0.001 | <0.001 | <0.001 |