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. 2017 Jun 29;12(6):e0178325. doi: 10.1371/journal.pone.0178325

Table 2. Probability of escalation to the next higher dose for each underlying true DLT rate.

True underlying DLT 5% 10% 20% 30% 40% 50% 60% 70% 80% 90%
Probabilty of escalating dose 0.97 0.91 0.71 0.49 0.31 0.17 .08 0.03 0.01 0.001
Probability of Failing to Observe toxicity if sample = 3 0.86 0.73 0.51 0.34 0.22 0.13 0.064 0.027 0.008 0.001
Probability of Failing to Observe toxicity if sample = 6 0.74 0.53
0.26
0.12 0.047 0.016 0.0041 <0.001 <0.001 <0.001 <0.001