Table 5.

Association between On-Statin Cholesterol Efflux Capacity and Incident Cardiovascular Events

	Tertile One	Tertile Two	Tertile Three	P-Trend	OR/SD Increment
Primary Endpoint
Range, %	5.85–11.87	11.88–15.54	15.55–25.31
N (N Cases/N Controls)	60 (31/29)	59 (29/30)	59 (20/39)
Model One
Odds Ratio (95%CI)	Reference	0.92 (0.45 – 1.90)	0.36 (0.16 – 0.84)	0.02	0.66 (0.47 – 0.94)
P-value		0.82	0.02		0.02
Model Two
Odds Ratio (95%CI)	Reference	0.79 (0.35 – 1.77)	0.31 (0.12 – 0.75)	0.01	0.62 (0.42 – 0.92)
P-value		0.57	0.01		0.02
Primary Endpoint + Total Mortality
Range, %	5.17–11.5	11.6–15.4	15.5–25.3
N (N Cases/N Controls)	83 (39/44)	82 (39/43)	83 (34/49)
Model One
Odds Ratio (95%CI)	Reference	1.04 (0.56 – 1.92)	0.64 (0.33 – 1.23)	0.20	0.86 (0.66 – 1.13)
P-value		0.90	0.18		0.27
Model Two
Odds Ratio (95%CI)	Reference	0.99 (0.5 – 1.94)	0.51 (0.25 – 1.04)	0.07	0.79 (0.59 – 1.07)
P-value		0.98	0.07		0.13

Model One: Odds ratio adjusted for age and treatment group. Model Two: Odds ratio adjusted for age, treatment group, race, smoking status, systolic blood pressure, body-mass index, fasting glucose, on-statin low-density lipoprotein cholesterol level, on-statin log-transformed triglyceride level, and family history of premature coronary artery disease. OR – Odds Ratio. P-trend – P-value for linear trend across tertiles.