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. 2017 Jun 29;12(6):e0178693. doi: 10.1371/journal.pone.0178693

Fig 4. Survival curves based on APNG and MGMT status.

Fig 4

Median survival in patients with low APNG and methylated MGMT promoter was 2.8/6.1 months (qIHC/IF) compared to 4.5/11.3 months in patients with low APNG expression and a un-methylated MGMT promoter. Patients with high APNG expression and un-methylated MGMT promoter had a median overall survival of 9.8/9.6 months whereas patients with high APNG expression and methylated MGMT promoter (H/M) had a median overall survival of 20.3/20.3 months (P < 0.001). In multivariate analysis patients with high APNG expression and methylated MGMT promoter demonstrated a better overall survival than patients with low APNG expression and methylated MGMT promoter; HR 0.55, P = 0.04 (qIHC) and HR = 0.66, P = 0.1 (IF). Abbreviations: u-MGMT un-methylated MGMT promoter, m-MGMT methylated MGMT promoter. APNG low/high was defined according to the optimal cut point, which was for qIHC was 0.24 and for IF was 0.75.