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. 2017 Jun 29;12(6):e0179530. doi: 10.1371/journal.pone.0179530

Fig 2. Comparison of performance of 6 methods in differential abundance analysis.

Fig 2

  • A) Schematic depicting the enzymatic steps in glycolysis pathway and the step where 2DG inhibits upon treatment. The metabolites shown in the diagram were analyzed by LC-MS.
  • B) Plot depicting the fraction of positive controls discovered by each method as significantly differentially abundant between the control and 2DG treated samples in the presence of batch effects.
  • C) Venn diagram comparing total number of discoveries made by each of the methods in the combined dataset (at 0.9 posterior probability for RRmix and 10% FDR correction for other methods).