. 2017 Jun 29;12(6):e0179745. doi: 10.1371/journal.pone.0179745

Table 3. Confocal microscopy characteristics and BRAF V600E mutation.

		BRAF V600E
Variable	Category	negative^a	positive^b	Total	P value
Atypical Honeycomb	Present	23 (71.9%)	9 (28.1%)	32	+
Atypical Cobblestone	Present	22 (73.3%)	8 (26.7%)	30	0.5
Atypical Cobblestone	Absent	1 (50.0%)	1 (50.0%)	2	0.5
Pagetoid cells	Present	12 (60.0%)	8 (40.0%)	20	0.1
Pagetoid cells	Absent	11 (91.7%)	1 (8.3%)	12	0.1
^Hyporreflective cells**	Present	3 (37.5%)	5 (62.5%)	8	0.02
^Hyporreflective cells**	Absent	20 (83.3%)	4 (16.7%)	24	0.02
^Epidermal nests**	Present	7 (50.0%)	7(50.0%)	14	0.02
^Epidermal nests**	Absent	16 (88.9%)	2 (11.1%)	18	0.02
^DEJ nests**	Present	11 (57.9%)	8 (42.1%)	19	0.05
^DEJ nests**	Absent	12 (92.3%)	1 (7.7%)	13	0.05
^Edged papillae**	Present	17 (85.0%)	3 (15.0%)	20	0.05
^Edged papillae**	Absent	6 (50.0%)	6 (50.0%)	12	0.05
Nonedged papillae	Present	23 (71.9%)	9 (28.1%)	32	+
^Abscence of papillae**	Present	1 (25.0%)	3 (75.0%)	4	0.06
^Abscence of papillae**	Absent	22 (78.6%)	6 (21.4%)	28	0.06
Sheet-like Structure	Present	12 (70.6%)	5 (29.4%)	17	1.0
Sheet-like Structure	Absent	11 (73.3%)	4 (26.7%)	15	1.0
^Meshwork**	Present	16 (88.9%)	2 (11.1%)	18	0.02
^Meshwork**	Absent	7 (50.0%)	7 (50.0%)	14	0.02
Mitochondria	Present	4 (80.0%)	1 (20.0%)	5	1.0
	Absent	19 (70.4%)	8 (29.6%)	27
	Absent	20 (69.0%)	9 (31.0%)	29
^Bright dots**	Present	17 (85.0%)	3 (15.0%)	20	0.05
^Bright dots**	Absent	6 (50.0%)	6 (50.0%)	12	0.05
Sparse Plump cells	Present	22 (75.9%)	7 (24.1%)	29	0.2
Sparse Plump cells	Absent	1 (33.3%)	2 (66.7%)	3	0.2
Agregated Plump cells	Present	8 (72.7%)	3 (27.3%)	11	1.0
Agregated Plump cells	Absent	15 (71.4%)	6 (28.6%)	21	1.0
Reticulated Collagen	Present	23 (71.9%)	9 (28.1%)	32	+
Collagen Bundles	Present	5 (83.3%)	1 (16.7%)	6	0.6
Collagen Bundles	Absent	18 (69.2%)	8 (30.8%)	26	0.6

**Fisher’s Exact Test

a. Negative: absence of staining

b. Positive: any positive staining (focal or multifocal).