Table 4. Clinical and histological characteristics of BRAF V600E mutated melanomas.

Case	Gender	Age	Local	Histological Type	Growth	Clark	Breslow	Mitotic index mm2	Peritumoral invasion*	Intratumoral Invasion*	Pre-existing. Nevus*	HRC (1)*	EN (2)*	DEJN (3)*	EP (4)*	AP (5)*	N (6)*	MS (7)*	BD (8)*
1	Female	45	Upper limbs	SS	In situ						0	1	0	1	1	1	1	0	0
2	Male	60	Upper limbs	SS	Radial	II	0.26	0	0	0	1	0	0	0	0	0	1	1	1
3	Female	47	Trunk	SS	Radial	III	0.79	1.25	1	0	1	1	1	1	0	0	1	0	0
4	Female	42	Head and neck	SS	Vertical	II	0.52	0	1	1	0	1	1	1	0	1	1	0	0
5	Male	61	Lower limbs	SS	Vertical	III	1	0	1	1	0	1	1	1	0	0	0	0	0
6	Female	28	Trunk	SS	Vertical	III	1	0	1	1	0	0	1	1	0	1	0	0	0
7	Female	62	Trunk	SS	Vertical	II	0.5	0	1	0	1	0	1	1	1	0	1	0	0
8	Male	47	Upper limbs	SS	Radial	III	0.71	0	1	1	0	1	1	1	1	0	1	1	1
9	Female	45	Upper limbs	SS	Radial	II	0.7	0	1	1	0	0	1	1	0	0	1	0	1

⁽¹⁾Hyporreflective cells

⁽²⁾Epidermal nests

⁽³⁾DEJ nests

⁽⁴⁾Edged papillae

⁽⁵⁾Abscence papillae

⁽⁶⁾Junctional thickening cell nests

⁽⁷⁾Meshwork

⁽⁸⁾Bright dots.

^*0 means absence of parameter and 1 means presence of parameter.

SS: Superficial Spreading