Table 7. Clinical, dermoscopic, confocal microscopy and histopathological features of positive and negative BRAF V600E melanomas.
BRAF V600E | Clinic | Dermoscopy | Confocal microscopy | Histopathology |
---|---|---|---|---|
POSITIVE | Age < 50 (p = 0,022); | Globular pattern with irregular globules; Blotches | Hyporeflective cells in epidermis (p = 0,21); Epidermal nests (p = 0,019); Junctional nests (p = 0,035); | Radial growth (p = 0,003); Vertical growth (p = 0,003) |
NEGATIVE | Age > 50 (p = 0,022); | Atypical network; Sparse irregular globules; Radial projections; Irregular hypopigmentation; Veil; Peppering | Edged papillae (p = 0,038); Junctional thickening cell aggregates (p = 0,012); Meshwork (p = 0,019); | In situ (p = 0,003) |