Table 1. In vitro activities of combination antibiotic treatment and PAAG.
| Species Tested | Strains Tested | MIC(μg/mL) | FICIMEM/TOB | FICIMEM/TOB/CAZ | FICIMEM/TOB/PAAG | |||
|---|---|---|---|---|---|---|---|---|
| MEM | TOB | CAZ | PAAG | |||||
| B. multivorans | AU10398 | 6 | 512 | 32 | >1024 | 0.39 ± 0.12 (S) | 4.1 ± 0.22 (NS) | 0.14 ± 0.11 (S) |
| B. cenocepacia | AU10321 | 24 | 128 | >1024 | >1024 | 0.42 ± 0.23 (S) | 0.3 ± 0.10 (S) | 0.15 ± 0.21 (S) |
| B. multivorans | AU2380 | 24 | 256 | >1024 | >1024 | 1.0 ± 0.32 (NS) | 4.25 ± 0.24 (NS) | 0.1 ± 0.14 (S) |
| B. multivorans | AU0064 | 24 | 256 | 32 | >1024 | 0.8 ± 0.14 (NS) | 4.1 ± 0.23 (NS) | 0.1 ± 0.12 (S) |
| B. cenocepacia | AU0007 | 24 | 256 | 128 | >1024 | 0.16 ± 0.16 (S) | 0.4 ± 0.14 (S) | 0.1 ± 0.13 (S) |
| B. cenocepacia | AU0037 | 12 | 128 | 8 | >1024 | 0.3 ± 0.13 (S) | 1.31 ± 0.14 (NS) | 0.15 ± 0.21 (S) |
| B. cepacia | ATCC 25416 | 6 | 256 | 128 | >1024 | 0.05 ± 0.21 (S) | 1.5 ± 0.12 (NS) | 0.12 ± 0.14 (S) |
| B. multivorans | EH4 | 6 | 256 | 64 | >1024 | 0.8 ± 0.12 (NS) | 2.5 ±0.14 (NS) | 0.15 ± 0.14 (S) |
Data is represented as the FICI values ± standard deviation. FICI values given are the lowest values for the given combination.
S = Synergy, NS = No synergy, MEM = Meropenem, CAZ = Ceftazidime, TOB = Tobramycin, FICI = Fractional inhibitory concentration index, MIC = Minimum inhibitory concentration.