Table 7. Transcription regulators significantly (p<0.05*) overrepresented among genes differentially expressed at 4°C vs. 20°C.
| Regulators | Regulon gene examples | p-value (# of contributing genes) | ||||
|---|---|---|---|---|---|---|
| G1 | G2 | G3 | G4 | G5 | ||
| Regulons upregulated | ||||||
| σB | inlA, bsh, mpoABCD, gabDE, opuCABCD, ltrC, csbD, phoU, hrcA | 3.70E-10 (63) | 3.95E-23 (69) | 1.26E-2 (8) | 9.58E-4 (51) | |
| CodY | argBDFJ | 1.96E-2 (4) | 4.70E-2 (4) | |||
| CtsR | clpBCEP, mcsAB, ctsR, gpmA | 1.74E-4 (8) | ||||
| HrcA | hrcA, grpE, dnaK | 4.14E-2 (3) | ||||
| Regulons downregulated | ||||||
| RpoD | dltABCD, plcAB, hly, mpl, actA, pmk, pgdA, ctaP, arcB | 1.91E-2 (24) | 4.57E-2 (16) | 1.05E-2 (14) | 1.59E-2 (39) | |
| VirR | dltABCD | 2.15E-2 (4) | 3.50E-4 (5) | 1.66E-3 (4) | ||
| PrfA | prfA, mpl, actA, plcB, inlC, hly | 1.16E-2 (5) | 4.44E-4 (5) | 3.14E-2 (6) | ||
| σB | mogR, mpoAB, phoU, ltrC, arsC, uspA | 2.14E-3 (52) | ||||
| MogR | fliNPQRK, cheRY, flhB, flgDE | 1.35E-2 (11) | ||||
* Statistical overrepresentation of gene sets were determined using Fisher’s exact test and the BioCyc database.