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. 2017 Jun 29;12(6):e0180258. doi: 10.1371/journal.pone.0180258

Fig 4. Pathway analysis of genes differentially expressed upon RBM10KD in GLC20 cells.

Fig 4

(A) KEGG pathways significantly enriched upon RBM10KD in GLC20 cells. Analysis performed using subline RNA-Seq expression data and the FIDEA pathways analysis program. (B) MSigDB Hallmark gene sets enriched at a false discovery rate of below 5% upon RBM10KD in GLC20 cells. Analysis performed using subline RNA-Seq expression data and the GSAASeqSP pathway analysis program. (C) Relationship between select RBM10-altered pathways in GLC20 cells. Hypoxia is associated with decreased levels of mTORC1 signaling, and promotion of EMT and angiogenesis. In addition, hypoxia is associated with increased levels of glycolysis, and likewise, survival in hypoxic conditions is promoted by increased levels of glycolysis. The influence of RBM10KD on these pathways, as determined by RNA-Seq is indicated.