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. 2017 Jul 1;28(13):1728–1737. doi: 10.1091/mbc.E17-01-0047

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© 2017 Solowska et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Hypothetical effects of premature termination codons 184X and 245X on stability of spastin mRNA. (A) Localization of spastin functional domains within 17 exons in spastin mRNA. The 184X termination codon UAA (red) is localized 7 bases upstream from the AUG of M187 initiation codon (green) and 35 bases upstream from exon 3/4 junction AG/AG (bold black). The 245X is localized in exon 5. (B) Pioneer round of translation of truncated 184X spastin would remove EJCs (red stars) from exons 1–3, and reinitiation of translation at M187 AUG would remove remaining EJCs from exons 4–16. (C) Pioneer round of translation of truncated 245X spastin would remove EJCs from exons 1–4. Remaining EJCs might render mRNA unstable.