Models of care in telehealth (A) and conventional settings (B). A, In a telehealth model, the patient and the health care provider are each geographically separated and connected using technology, such as through the use of text messages, telephones, or telemedicine (ie, 2-way videoconferencing between a patient and a physician each located remotely). Technology can also be used to transmit data from a physician to a patient, vice versa, or between physicians. For example, a patient portal enables patients to view their test results, remote patient monitoring permits results (ie, glucose or blood oxygenation) to be transmitted from a patient to a physician, and digital images can be transmitted for remote review by a radiologist. B, In conventional health care settings, persons with substance use disorders are typically referred to a health care provider to obtain treatment for hepatitis C virus infection. Alternatively, a health care provider could engage directly with persons with substance use disorders through an integrated care model in which hepatitis C virus care is delivered directly in the venue that offers treatment for substance use. Case management, patient education, peer navigation, and patient navigation are important interventions that can support persons with substance use disorders access to care and adherence.