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Four-week Met and IOs treatment strongly reduced the serum levels of GSK-3 (A), and increased the level of the hepatic glycogen (B) and muscle glycogen (C) in STZ-induced diabetic mice. Data are expressed as mean ± S.E.M. (n = 10) and analyzed by using a one-way ANOVA. # P < 0.05 and ## P < 0.01 versus control, * P < 0.05, ** P < 0.01 and *** P < 0.001 versus model group, ^ P < 0.05 and ^^P < 0.01 versus Met-treated group.
