Table 1.
Patient demographics
| Characteristics | Acute Rejection (n=7) | Chronic Active Rejection (n=13) | Chronic Rejection (n=12) |
|---|---|---|---|
| Age, yr | 51±8.16 | 48.69±9.35 | 50.92±8.13 |
| Men/women, n | 6/1 | 8/5 | 10/2 |
| Timing of biopsy post-transplantation, mo | 0.51±0.21 | 79.47±66.11 | 104±76.26 |
| SCr, μmol/L | 259.14±140.19 | 267.67±86.01 | 184.36±55.60 |
| Hypertensiona (Y/N), n | 1/6 | 2/11 | 3/9 |
| Proteinuriab (Y/N), n | 2/5 | 2/11 | 3/9 |
| eGFR<60 ml/min (Y/N), n | 6/1 | 12/1 | 10/2 |
| Immunosuppressive, n | |||
| Tac+MMF+steroid | 4 | 6 | 4 |
| CyA+MMF+steroid | 2 | 4 | 4 |
| CyA+Aza+steroid | 0 | 1 | 2 |
| CyA+steroid | 1 | 2 | 2 |
| Banff scores | |||
| Interstitial infiltrate (i) | 0.86±0.64 | 1.62±0.62 | 0.50±0.50 |
| Tubulitis (t) | 0.57±0.49 | 0.92±0.62 | 0.17±0.37 |
| Intimal arteritis (v) | 0.43±0.49 | 0.54±0.63 | 0.42±0.49 |
| Glomerulitis (g) | 0.29±0.45 | 1.23±0.97 | 0.92±0.76 |
| Interstitial fibrosis (ci) | 0.00±0.00 | 1.31±0.72 | 1.50±0.65 |
| Tubular atrophy (ct) | 0.00±0.00 | 1.38±0.62 | 1.42±0.76 |
| Vascular fibrous intimal thickening (cv) | 0.00±0.00 | 0.23±0.42 | 1.08±0.49 |
| Allograft glomerulopathy (cg) | 0.00±0.00 | 0.85±0.86 | 1.17±0.69 |
The data are presented as mean±SEM. SCr, serum creatinine; Y, yes; N, no; Tac, tacrolimus; MMF, mycophenolate mofetil; CyA, cyclosporine A; Aza, azathioprine; i, interstitial infiltrate; t, tubulitis; v, intimal arteritis; g, glomerulitis; ci, interstitial fibrosis; ct, tubular atrophy; cv, vascular fibrous intimal thickening; cg, allograft glomerulopathy.
a
BP≥140/80 mmHg at time of biopsy.
b
Proteinuria≥0.5 g/24 h at time of biopsy.