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. 2017 Jan 30;28(7):2007–2021. doi: 10.1681/ASN.2016091001

Figure 11.

Figure 11.

Rtn1a knockdown in renal tubular cells attenuated the early expression of ER stress and apoptosis markers and subsequent expression of renal fibrosis markers in mice with FAN. (A) Real-time PCR analysis of ER stress markers in mouse kidneys at 5 days postinjection. (B) Western blot analyses of markers of ER stress and apoptosis at 5 days postinjection. (C) Densitometric analysis of RTN1A, CHOP, and cleaved caspase-3 in kidney lysates of mice 5 days postinjection. (D) Real-time PCR analysis of fibrosis markers at 6 weeks postinjection. **P<0.01 and ***P<0.001 compared with vehicle-treated control mice; ##P<0.01 and ###P<0.001 compared with AA-injected LuciRNAi mice (n=5 in each group).