Figure 4.
Expression of XBP-1s was decreased in kidneys of patients with AKI. (A) Immunostaining of XBP-1s in kidney sections of patients with AKI. The representative images are shown for each group. Original magnification, ×400. (B) Semiquantitative scoring of XBP-1s staining for both glomerular and tubular interstitial compartments was summarized in a bar graph. *P<0.05, compared with normal; #P<0.05, compared with stage 1. (C–E) Decreased expression of XBP-1s in tubular compartment was correlated inversely with renal function in patients with AKI using Pearson correlation analysis. P and R2 are indicated on the graph; n=51. (F) Immunostaining of XBP-1s in kidney sections of AKI stage 3 patients with or without disease progression. The representative pictures are shown for both nonprogressive and progressive groups. (G) Semiquantitative scoring of XBP-1s staining in kidneys of both nonprogressive and progressive AKI stage 3 patients is summarized in a bar graph. Glom, glomerular; Tub, tubular.