Table 1.
Association findings for SNP rs116907128, which lies within the 2q11.2–q14.1 locus identified by admixture mapping
| Study | Alleles | A allele frequency | UACRa | eGFR P Value | Type 2 Diabetes | Diabetic Nephropathyb | |||
|---|---|---|---|---|---|---|---|---|---|
| β (SEM) | P Value | OR | P Value | OR (95% CI) | P Value | ||||
| HCHS/SOL study | A/C | 0.14 | 0.11 (0.02) | 1.5 × 10−7 | 0.97 | 0.99 | 0.79 | NA | |
| Full-heritage Pima Indiansc | A/C | 0.54 | 0.32 (0.13) | 9.6 × 10−3 | 0.85 | 1.07 | 0.33 | 1.22 (1.01 to 1.48) | 0.04 |
OR, odds ratio; 95% CI, 95% confidence interval; NA, not available.
a
Test for heterogeneity estimated from HCHS/SOL Hispanics/Latinos and Pima Indians not significant (Q=2.55 on 1 degrees of freedom; P=0.11).
b
Diabetic nephropathy defined as case (UACR≥300 mg/g or ESRD; n=398) versus control (UACR<300 mg/g; n=1251) for a total of n=1649.
c
UACR (n=1568); eGFR (n=1552); type 2 diabetes (total n=3699; 1724 cases; and 1975 controls).