Table 3.
Association of SCT and hemoglobin C trait with prevalent CKD and incident ESRD after adjustment for PCA
| Variables | Noncarriers | SCT | Hemoglobin C Trait |
|---|---|---|---|
| Prevalent CKD | |||
| N (%) | 1601 (24.9) | 193 (37.6) | 41 (23.9) |
| Adjusted OR (95% CI) | 1.00 (ref) | 1.93 (1.57 to 2.37) | 0.81 (0.55 to 1.21) |
| Incident ESRD | |||
| N (%) | 143 (2.13) | 26 (4.85) | 3 (1.67) |
| Incidence rate (N/1000 person-yr) | 3.9 | 10.0 | 3.9 |
| Adjusted HR (95% CI) | 1.00 (ref) | 2.38 (1.57 to 3.61) | 0.81 (0.30 to 2.20) |
Prevalent CKD was defined as a baseline eGFR<6 0ml/min per 1.73 m2 and/or UACR≥30 mg/g. All models were adjusted for age, sex, smoking, diabetes, hypertension, APOL1 high-risk genotype status, and were additionally adjusted for PCA in this subset. PCA, principal components of ancestry; SCT, sickle cell trait; ref, reference.