Figure 7.

Histologic examination shows exacerbated glomerular injury in APA-KO mice after chronic AngII infusion. (A) Representative light microscopy images of kidney sections stained with Masson trichrome. Tissue was harvested from wild-type (wt) or APA-KO mice treated with chronic subcutaneous infusion of either vehicle control (Ctrl) or AngII (400 ng/kg per minute) for 4 weeks. (B and C) Bar graphs show comparison of the percentages of juxtamedullary glomeruli with segmental (III, IV, and VII) or global (V and VI) sclerosis, collapse (V and VIII), or microaneurysms (IV and VIII). (D) Evidence of glomerular enlargement was compared between groups. *P<0.01. Scale bars, 200 μm.