Figure 9.

Podocyte protein expression changes observed in APA-KO mice after chronic AngII infusion. Representative images depicting the effect of chronic infusion of AngII on (A) nephrin and β-actin as examined by Western blotting in whole-kidney homogenates and (B) nephrin and ZO-1 expression as examined by immunofluorescence in 5 µm kidney sections. Graph shown next to the Western blot reflects quantification of band densities from five individual mouse kidney homogenates from the wild-type (wt) control (Ctrl) group and six of each of the other three treatment groups. *P<0.01.