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. 2017 Jun 29;7:4391. doi: 10.1038/s41598-017-04586-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of AG treatment on selenoprotein transcript levels. HepG2 cells were treated with G418, gentamicin or Se for 48 h and mRNA expression was determined by qRT-PCR using 18 S rRNA as reference. (A) DDIT3 served as control gene for AG effects, and transcript levels increased in response to AG treatment in a dose-dependent manner. (B–C) Supplemental selenite and G418 increased SELENOP (SEPP1) and GPX1 transcript levels. (D) Supplemental selenite or gentamicin had no effect on GPX2 transcript levels, whereas G418 showed a moderate effect. (Mean ± SEM, n = 4, ANOVA followed by Dunnett’s).