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. 2017 Jun 29;7:4391. doi: 10.1038/s41598-017-04586-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of AG treatment on selenoprotein expression in mice. Mice fed Se-deficient or Se-sufficient diets were treated with G418 or gentamicin. (A) Ddit3 was analyzed as an AG-responsive gene in kidney and liver, and significantly increased Ddit3 mRNA concentrations were observed in kidney upon G418 injection (ANOVA followed by Dunnett’s). (B) Western blot analyses of Gpx3 and Selenop showed no differences in expression levels in response to G418 or gentamicin in Se-treated or Se-deficient mice. (C) Se concentrations were higher in the selenite-supplemented mice than in mice raised on a Se-deficient diet. No effect of AG treatment on serum Se was detectable. (D) Se concentrations of precipitated protein from serum were higher in Se supplemented than in Se-deficient mice. Differences between the AG treatment groups were not detectable. (Mean ± SEM, n = 7).