Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 29;7:4379. doi: 10.1038/s41598-017-04728-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Synthesis and photolysis of caged dopamine. (A) Synthetic rout to caged dopamine (CNV-dopamine, 5 and 6). See methods for detailed explanation. (B) The caged dopamine compound was photolysed with LED flashes of 365 nm. When flashes were conducted with a 60 second interval, there was little to no rundown of the resultant D2-GIRK current with flash lengths up to 100 ms. Even with longer 500 ms flashes, only a modest decrease in current was observe. This was likely due to receptor desensitization rather than compound rundown. (C) All flash-induced currents were completely abolished by the addition of sulpiride to the caged dopamine reperfusion solution indicating the dopamine being uncaged acted solely on the D2 receptor. (D) Application of the dopamine transporter (DAT) blocker cocaine increases the amplitude and prolongs the signaling of the flash currents indicating that the uncaged dopamine is taken up through the DAT.