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. 2017 Jun 29;7:4363. doi: 10.1038/s41598-017-04718-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumor spheroid dissemination assay. (a) Design concept of the tumor dissemination assay by PDMS-HDA. (b) Example of in-situ transfer of the cell spheroid-containing drop array (4*4 array highlighted by blue dyes; 11 μl per drop) from the device to the appropriate cell-examined substrate (e.g. cell culture dish). (c) Time-sequenced images showing the dissemination of HCT116 spheroids over a 3-day culture, in which cells were treated with irradiation, NU7441, or combined treatment from day 0. Scale bar, 200 μm. (d) Spheroid migration area correspondingly measured from day 0 to 3. Each data represents the mean ± SEM from 2 independent experiments (n = 17~29; **p < 0.01, ***p < 0.001).