Table 4.
Main findings from PET tau studies using [18F]AV-1451
| Paper | Tracer | Clinical population | Findings |
|---|---|---|---|
| Xia (2013)52 | [18F]AV-1451 | In vitro | Autoradiography signal matching PHF tau; Favorable pharmacokinetics |
| Marquie (2015)53 | [18F]AV-1451 | In vitro CBD (n = 2), PSP (n = 3), AD (n = 3), HC (n = 2) | Autoradiography consistent with tau pathology in AD; No signal in non-AD (non PHF-tau) taupopathies; Binding to neuromelanin-containing cells in all cases |
| Sander (2016)54 | [18F]AV-1451 | In vitro CBD (n = 4), PSP (n = 6), Pick’s disease (n = 5), AD (n = 5) | Autoradiography signal consistent with tau pathology in AD and Pick’s disease; No signal in CBD and PSP |
| Lowe (2016)55 | [18F]AV-1451 | In vitro CBD (n = 2), FTLD-17 (n = 5), PSP (n = 3), AD (n = 3), HC (n = 3) | Signals consistent with tau pathology in AD and aging; No signal in non-AD tauopathies; Binding in midbrain in all cases |
| Chien (2013)56 | [18F]AV-1451 | AD (n = 2), MCI (n = 1), HC (n = 3) | Binding consistent with AD tau pathology; ↑ SUVR in temporal lobes and hippocampal area in AD compared to MCI and HC |
| Schwarz (2016)57 | [18F]AV-1451 | AD (n = 44), MCI (n = 87), old HC (n = 42) | Binding consistent with tau pathology in AD and HC aging |
| Sepulcre (2016)58 | [18F]AV-1451 | Old HC (n = 88) | Binding associated with atrophy in temporal lobe |
| Scholl (2016)59 | [18F]AV-1451 | Young HC (n = 5), old HC (n = 33) | ↑ binding in medial temporal lobe related to aging; Binding associated with cognitive decline |
| Cho (2016)60 | [18F]AV-1451 | AD (n = 20), MCI (n = 15), HC (n = 20) | Binding consistent with tau pathology in AD and MCI; ↑ binding in AD compared to MCI and HC; ↑ binding in MCI compared to HC; Binding associated with cognitive decline and cortical atrophy |
| Ossenkoppele (2016)61 | [18F]AV-1451 | AD/MCI subtypes (n = 20), HC (n = 15) | Binding varied between AD/MCI subtypes; Binding in medial temporal lobe associated with aging |
| Chhatwal (2016)62 | [18F]AV-1451 | Old HC (n = 31) | Binding correlated with cerebrospinal fluid total-tau and phosphorylated-tau in temporal lobe |
| Smith (2016)63 | [18F]AV-1451 | PSP (n = 11), HC (n = 11) | ↑ SUVR in globus pallidus, putamen, thalamus and midbrain in PSP compared to HC; Binding consistent with tau pathology in PSP and correlated with PSPRS scores; Overlap in binding between PSP and HC |
| Whitwell (2016)64 | [18F]AV-1451 | PSP (n = 10), AD (n = 10), HC (n = 50) | Binding consistent with tau pathology in PSP and correlated with PSPRS scores; ↑ binding in PSP compared to HC; Overlap in subcortical binding between PSP and HC; PSP SUVR low relative to high binding in AD |
| Cho (2016)65 | [18F]AV-1451 | PSP (n = 15), PD (n = 15), HC (n = 15) | Binding consistent with tau pathology in PSP; ↑ binding in PSP compared to PD and HC; No correlations with PSPRS scores |
| Coakeley (2016)66 | [18F]AV-1451 | PSP (n = 6), PD (n = 6), HC (n = 10) | No significant differences in PSP binding compared to PD and HC; No correlations with PSPRS scores |
| Passamonti (2017)67 | [18F]AV-1451 | PSP (n = 19), AD (n = 9), MCI (n = 6) | ↑ binding in cortical regions of AD and MCI compared to PSP; ↑ binding in midbrain, putamen, pallidum, thalamus, dentate nucleus in PSP compared to AD and MCI; No correlations with PSPRS scores |
| Marquié (2017)68 | [18F]AV-1451 | PSP (n = 2), MAPT carrier (n = 1) | ↑ binding in substantia and midbrain in PSP and MAPT carrier; No autoradiography signal in PSP and MAPT carrier |
| Josephs (2016)69 | [18F]AV-1451 | CBD (n = 1) | Binding consistent with tau pathology in CBD; Binding correlated with tau pathology at autopsy; Autoradiography signal in 3R tau isoform but not 4R tau isoform |
| McMillan (2016)70 | [18F]AV-1451 | CBD (n = 1) | Binding consistent with tau pathology in CBD; ↑ binding in follow-ups compared to baseline scan; Binding correlated with tau pathology at autopsy |
| Ono (2017)71 | [18F]AV-1451 | In vitro PSP, CBD, Pick’s disease, FTDP-17 with N279 and G272 MAPT mutation | ↑ signal of PBB3 in non-AD tauopathies compared to AV-1451 signal |
| Vermeiren (2015)72 | [18F]AV-1451 | In vitro | Possible off-target binding to MAO-A |