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. 2017 Jun 29;7:4364. doi: 10.1038/s41598-017-04231-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of a P2X7R blockade on receptor expression and survival rates. The protein levels of P2X7R in intestines from mice that received intraperitoneal injections of BzATP or A740003 before CLP procedures (A) and 48 hours after CLP procedures (B) measured by WB. N = 6 mice per group. The results of the WB analysis are combined data from three densitometric scans (mean ± SD). (C) The Kaplan-Meier survival curve 48 hours after CLP. Twenty-four hours after CLP, mice received saline (control group, N = 20), BzATP (BzATP-treated group, N = 20), or A740003 (A740003-treated group, N = 20). The mice in the sham control group that underwent sham surgery (sham group, N = 6) were intravenously injected with saline. The Kaplan-Meier survival curves were compared by the log-rank test. *p < 0.05, **p < 0.01 and ***p < 0.001 when compared among the different groups.