Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 29;7:4364. doi: 10.1038/s41598-017-04231-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effects of a P2X7R blockade on intestinal permeability and bacterial translocation. In vivo and in vitro permeability and bacterial translocation were assessed at 48 hours after CLP. (A) Mice in each group were fasted for 4 hours and then administered FD-40. Serum FD-40 was measured to evaluate in vivo permeability. (B,C) The in vitro permeability of the mouse intestines was measured by performing Ussing Chamber Analyses. (D) The MLN, CLN, blood, and PF were collected and cultured at 37 °C for 24 hours. The culture results of bacterial growth were considered positive when more than 10² colonies/g of tissue were found. N = 6 mice per group. The data are expressed as the means ± SD. *p < 0.05, **p < 0.01 and ***p < 0.001 when compared among the different groups.