. Author manuscript; available in PMC: 2018 Jul 15.

Published in final edited form as: Int J Cancer. 2017 Apr 26;141(2):271–278. doi: 10.1002/ijc.30737

Table 4.

Associations of body mass index (BMI) trajectories with incidence of HCC and ICC, the NIH-AARP study

BMI trajectory	HCC incidence			ICC incidence

	Events, n	Person-years	Adjusted HR (95% CI)^a	Events, n	Person-years	Adjusted HR (95% CI)^a
Stable normal	85	1,341,465	Ref	33	1,341,465	Ref
Normal to overweight	190	1,694,816	1.28 (0.99, 1.67)	51	1,694,816	1.14 (0.73, 1.79)
Normal to obese class II	42	264,975	1.84 (1.25, 2.70)	10	264,975	1.54 (0.74, 3.21)
Overweight to obese class I	43	225,366	1.71 (1.17, 2.50)	7	225,366	1.14 (0.49, 2.63)
Overweight to obese class III	12	71,474	1.83 (0.98, 3.42)	3	71,474	1.76 (0.52, 5.96)

Abbreviations: BMI, body mass index; CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; ICC, intrahepatic cholangiocarcinoma.

Adjusted for age at baseline, sex, physical activity, cigarette smoking, alcohol consumption, history of diabetes, and red meat consumption.

Note: underweight, BMI < 18.5 kg/m²; normal weight, BMI 18.5 – < 25.0 kg/m²; overweight, BMI 25 – < 30 kg/m²; obese class I, BMI 30 – < 35 kg/m²; obese class II, BMI 35 – < 40 kg/m²; obese class III, BMI ≥ 40 kg/m²