FIGURE 7.

Comparison of fungal burden in neonate mice after the 1 × 10⁷ dose of WT CLIB, och1Δ/Δ and och1Δ/Δ+OCH1 infection. Newborn (1 × 10⁷/20 μl) mice were infected with the C. parapsilosis CLIB 214 (WT CLIB), the cell wall mutant (och1Δ/Δ) and the reintegrated (och1Δ/Δ+OCH1) strain. CFUs in spleen (A), kidney (B), liver (C), and brain (D) at day 2 and 7 post-infection are shown. Results (mean ± SEM) are pooled data from two independent experiments (n = 4 mice/group/experiment). Not significant (ns), ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, and ^∗∗∗∗p < 0.0001 when compared to the WT CLIB infected mice group as determined by Mann–Whitney U-test.