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. 2017 Jun 30;8:1197. doi: 10.3389/fmicb.2017.01197

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Copyright © 2017 Csonka, Vadovics, Marton, Vágvölgyi, Zajta, Tóth, Tóth, Vizler, Tiszlavicz, Mora-Montes and Gácser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology during systemic WT CLIB, och1Δ/Δ, and och1Δ/Δ+OCH1 C. parapsilosis infection in neonate mice. Sections were stained with periodic acid-Schiff (PAS) stain. Fungal cells (indicated by arrowheads) are evident in the organs of mice infected with the C. parapsilosis CLIB 214 (WT CLIB) (B spleen, F kidney, J liver, N brain), the och1Δ/Δ (C spleen, G kidney, K liver, O brain) and the och1Δ/Δ+OCH1 (D spleen, H kidney, L liver, P brain) strain. (A spleen, E kidney, I liver, M brain) Control organs from PBS-injected mice. All observations of the infected organs were performed at day 2 of 2 × 10⁷/20 μl dose of infection. Scale bar represents 100 μm.