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. 2017 Jun 30;8:756. doi: 10.3389/fimmu.2017.00756

Figure 1.

Figure 1

ICOS is a relevant target in xeno-graft-vs-host disease. (A) Representative profiles of ICOS/CD45RA expression on human CD3+ T cells in the blood before (D0) and 11 days (D11) after peripheral blood mononuclear cell (PBMC) injection into NSG mice. (B) Frequencies of ICOShi CD45RA− population in CD3+ human T cells before injection (D0) and in the blood of NSG mice 11–15 days after injection (D11–D15). Results are compiled from two independent experiments, and each symbol represents an individual mouse or single healthy donor. The means for each group are represented by the horizontal line. (C) Representative profile of Ki-67 expression for ICOS− and ICOS+ CD3+ T cells in the blood of NSG mice at D15 post-PBMC transfer. FMO = Fluorescence minus one control (all markers except Ki-67).