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. 2017 Jun 30;8:739. doi: 10.3389/fimmu.2017.00739

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Copyright © 2017 Tousif, Singh, Mukherjee, Ahmad, Arya, Nanda, Ranganathan, Bhattacharyya, Van Kaer, Kar and Das.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-treatment of curcumin nanoparticles with INH reduces inflammatory lesions in liver and hepatotoxicity caused by ATT. (A) Macroscopic pathology of liver at different time points after infection. Mice infected with a low-dose aerosol inoculum of Mycobacterium tuberculosis H37Rv (~110 colony forming unit/mice) were sacrificed 40 days postinfection, and liver was obtained and photographed to study the comparative changes in gross pathology of the liver. (B) Hepatotoxicity. For comparative evaluation of hepatotoxicity in the different experimental groups, we assessed serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels in serum at different time points. The figure shows serum ALT, AST, and ALP levels as indicators of hepatotoxicity in different experimental groups at 50 days postinfection.