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. 2017 Jun 30;11:178. doi: 10.3389/fncel.2017.00178

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Copyright © 2017 Brzdak, Nowak, Wiera and Mozrzymas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain structure and brain expression of different metzincins described in the review article. The domain organization of metalloproteinases (MMPs) (A), adamlysins (B) and astacins (C). Sig, signal peptide; Pro, propeptide; Fu, Pro-protein convertase (furin) cleavge site; H, hinge region; Fn, fibronectin type II motif; TM + CD, transmembrane type I domain with cytoplasmic domain; GPI, Glycosylphosphatidylinositol-anchoring sequence; Cys, cysteine-rich domain; Ig, immunoglobulin-like domain; Dis, disintegrin domain; Thr, thrombospondin type I-like domain; MAM, meprin/A5-protein/PTPmu domain; TRAF, MATH/TRAF domain; I, inserted domain; EGF, epidermal growth factor-like domain; CUB, complement C1r/C1 s, Uegf, Bmp1 domain. Meprin α contains proteolytic processing sequence in inserted domain, that is essential for the production of soluble meprin α if not coexpressed with meprin β. (D) List of metzincins that are confirmed to be expressed by oligodendrocytes, astrocytes and neurons in the central nervous system (CNS).